Fig. 1: Biochemical and structural features of human GLT25D1/COLGALT1. | Nature Communications

Fig. 1: Biochemical and structural features of human GLT25D1/COLGALT1.

From: Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1

Fig. 1: Biochemical and structural features of human GLT25D1/COLGALT1.

a Reaction scheme showing the collagen Lys–to–Glc-Gal-Hyl conversion post-translational modification process mediated by the alternate action of LH/PLOD and GLT25D1/COLGALT1, with color highlight of donor substrates and associated products. b Cartoon representation of the crystal structure of human GLT25D1/COLGALT1, showing the domain architecture of the enzyme with GT1 and GT2 domains connected via a rigid linker element, anchored to both domains via hydrophobic anchorages shown in details in (c).

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