Fig. 1: Development and characterization of epitope optimized (Epigraph) vaccine immunogens.
From: Epitope-optimized vaccine elicits enduring immunity against swine influenza A virus
A Phylogenetic characterization of classical swine and human-seasonal swine influenza A virus lineages with localization of Epigraph and WT vaccine immunogens. B Epicover analysis of exact-matched, off-by-1, and off-by-2 epitope coverage in Epigraph, WT, or representative strains in a commercial vaccine. C Immunoblots of Epigraph and WT vaccine expression from infected cell lysates. Data are representative of two independent experiments. D Percent amino acid identity between virus strains used throughout the study and the individual Epigraph or WT vaccine immunogens.
