Fig. 2: Epigraph induces robustly cross-protective immunity in mouse model.
From: Epitope-optimized vaccine elicits enduring immunity against swine influenza A virus
A Schematic representation of study design in mice. Weight loss, peak weight loss, lung viral titers, and survival analysis after a two-dose immunization and experimental infection with B representative α clade (1A.1) IAV-S, A/swine/USA/1976/1931 (n = 5 mice for each group; one-way ANOVA with Tukey’s multiple comparisons), C γ clade (1A.3.3.3) IAV-S, A/swine/Minnesota/9606/2015 (n = 5 mice for each group; one-way ANOVA with Tukey’s multiple comparisons), or D δ1 clade (1B.2.2) IAV-S, A/swine/Arkansas/6312/2012 (n = 5 mice for each group; one-way ANOVA with Tukey’s multiple comparisons). Dashed lines in weight loss curves indicate threshold for ≥25% weight loss. Dashed lines in viral RNA quantification and lung viral titer graphs indicate assay limits of detection. Data are presented as the mean ± SEM. Created in BioRender. Madapong, A. (2025) https://BioRender.com/8dqpzbw.
