Fig. 4: Comparisons between HEROVision and six major guideline methods.

For TA (a, b) and SR (c, d) datasets, the C-index values in the training, internal validation, and external testing cohorts (a, c), along with the time-dependent AUCs in all three cohorts (b, d), shows that HEROVision consistently outperformed all six major staging systems proposed by different guidelines for prognostic prediction. Furthermore, there were noticeable enhancements in 2-year C-index and AUC for the six staging systems, after they were supplemented with HEROVision for both 2ndTA (e, f) and 2ndSR (g, h) datasets. Source data are provided as a Source Data file. TA thermal ablation, SR surgical resection, C-index concordance index, AUC area under the curve, AJCC American Joint Committee on Cancer, BCLC Barcelona Clinic Liver Cancer, CNLC China Liver Cancer, HKLC Hong Kong Liver Cancer, ITA.LI.CA Italian Liver Cancer, UICC Union for International Cancer Control.