Fig. 5: Mapping of mesenchymal cell in vivo distribution during development using integrated analysis of E12.5, E13.5, and E15.5 spatial genomics data.

a–r TissUUmaps spatial plots of E12.5, E13.5, and E15.5 hard and soft palate regions from an integrative analysis of palatal spatial genomics data, with color keys displayed on the left. Different cell clusters are represented by distinct colors. For the hard palate region, individual clusters are shown as follows: osteogenic clusters 12 and 25 (a–c), odontogenic clusters 28 and 54 (d–f), and midline cluster 62 (g-i). For the soft palate region, individual clusters are represented as follows: perimysial cluster 51 (j–l), midline cluster 72 (m–o), and fibroblastic cluster 38 (p–r). Schematic drawings of section orientation and levels are depicted in light blue above the main panels. Black arrows indicate the locations of the respective cell clusters. Abbreviations: muscle mass (mm), odontogenic epithelium (oe), palatal epithelium (pe), and tensor veli palatini (tvp).