Fig. 9: URI depends on p53 to promote tumour initiation.

a Scheme of the vil-Cre-ER^T2; p53^lox/lox; Myc^lox/lox mouse models. b Experimental design for the tumorigenesis in these mice. c H&E of the intestinal tumours found in p53^(Δ/Δ)vil; Myc^(+/+)vil mice; and p53^(Δ/Δ)vil; Myc^(Δ/Δ)vil mice. d Percentage of mice presenting tumours in these models. e Number of tumours found in the indicated mice (n = 8, 17). f IF staining of URI in a tumour from p53^(Δ/Δ)vil; Myc^(+/+)vil mice. g Scheme of the vil-Cre-ER^T2; p53^lox/lox; URI^lox mouse model. h Experimental design for tumorigenesis in these mice. i Pictures of H&E staining of intestinal tumours found in p53^(Δ/Δ)vil; URI^(+/+)vil and p53^(Δ/Δ)vil; URI^(+/Δ)vil mice. j Proportion of mice presenting intestinal tumours. k Number of intestinal tumours found in these mice (n = 8, 34). l Experimental design for ageing experiments in these mice. m Kaplan-Meier curve indicating survival probability and time (in days) of the corresponding mice. n Scheme of the vil-Cre-ER^T2; p53^lox/lox; villin-rtTA; ColA1-tetO-hURI mouse model. o Experimental design for the tumorigenesis in these mice. p Pictures of H&E staining of intestinal tumours found in p53^(Δ/Δ)vil; hURI^(+/+)vil mice and p53^(Δ/Δ)vil; hURI^(+/KI)vil mice. q Proportion of mice presenting intestinal tumours. r Number of intestinal tumours found in these mice (n = 24, 8). s Scheme of the hUb-CreERT2; p53^lox/lox; URI^lox mouse model. t Experimental design for tumorigenesis in these mice. u Kaplan-Meier curve indicating survival probability and time (in days) of p53^(Δ/Δ)Ub; URI^(+/+)Ub and p53^(Δ/Δ)Ub; URI^(+/Δ)Ub mice. v Percentage of mice presenting tumours in the indicated tissues. DIC = mouse dead in cage. Bars represent the mean, except in (v). Error bars represent the standard error of the mean (SEM). Dots represent individual mice. Two-sided t. test was used to compare the statistical differences between means of two different groups. Source data are provided as a Source Data file.