Fig. 5: Conformational changes of NBDs in different states.

a Changes in distance between the two NBDs in the five states. The distances at the degenerate site are measured between Gly371 of MsRv1273c and Ser529 of MsRv1272c, and the distances at the consensus site are measured between Ser473 of MsRv1273c and Gly427 of MsRv1272c. The position of all the measured residues is indicated by red spheres. b Superposition of NBDs of MsRv1272c in the five states. The shifts of D-WalkerB loop and X-signature loop are marked with red double headed arrows. c Conformational changes of NBD of MsRv1272c from IF^apo state (cyan) to IF^asym−1 state (gray). Important residues are shown as sticks. Shifts of helices and residues are marked with red arrows. d Separate views of the degenerate site for the five states show the conformational changes of the D-WalkerB loop and X-signature loop.