Fig. 1: CryoEM density for the spermine-bound hVPATEM.
From: Structure and mechanism of human vesicular polyamine transporter
a, b The cryoEM density for the spermine-bound hVPATEM as viewed from the membrane, with the membrane bilayer simplified as a gray rectangle. CryoEM density for the mVenus, N- and C-domain of hVPAT, and nanobody is colored green, blue, orange, and light green, respectively; whereas the density for spermine and water molecules is shown in magenta and red, respectively. The cryo-EM density is contoured at 7.0 in ChimeraX v.1.8. c The luminal view highlights the solvent-accessible spermine-binding site. The cryoEM density is contoured at 7.0 in ChimeraX v.1.8. d Two close-up views showcasing the fitting of the spermine (magenta sticks) into the cryoEM density (magenta). The cryo-EM density is contoured at 8.5 in ChimeraX v.1.8.
