Fig. 5: Identification of intrinsic biological characteristics associated with the activation of EGFR/MAPK pathway following anti-EGFR therapies. | Nature Communications

Fig. 5: Identification of intrinsic biological characteristics associated with the activation of EGFR/MAPK pathway following anti-EGFR therapies.

From: Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer

Fig. 5

a Cophenetic coefficient at various values of k test (k = 2–8). K = 2, with a cophenetic coefficient of 0.9752, was chosen. b Consensus patient similarity matrix depicting clusters (k = 2). The pie chart depicts the fraction of patients in each subtype with acquired mutations. c Heatmap patient samples sorted by NMF cluster assignment in the column, and the most significantly (FDR corrected Krueskal Wallis p-value < 0.05) NMF associated MSigDb hallmark pathways and xCell cell types clustered in row. P-value determined using a Kruskal-Wallis rank sum test. d Changes in tumor volume from baseline to 3 weeks post-cetuximab treatment in 244 PDX models with NMF 2.1(N = 221) and NFM2.2 (N = 23) tumors. The box and whisker plot shows the median, quartiles (hinges), whiskers, and individual outliers. P-value determined using a two-sided Wilcoxon rank sum test. Source data for panels (c and d) are provided as a Source Data file.

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