Fig. 1: Overview of analytical framework for multi-omic integration to study the biological processes underlying neurodegeneration.
From: An integrative systems-biology approach defines mechanisms of Alzheimer’s disease neurodegeneration
We performed a forward genetic screen for age-associated neurodegeneration in Drosophila. We measured proteomics, phosphoproteomics and metabolomics in amyloid β (gold) and tau (purple) models of Alzheimer’s disease and performed an eQTL meta-analysis of previous Alzheimer’s disease studies. We used a network integration model to integrate these new data with previously published human proteomics, human genetics, human lipidomics, and Drosophila modifiers of tau-mediated neurotoxicity. We tested hypotheses inferred from subnetwork analysis of the network model in Drosophila and human iPSC-derived neural progenitor cells. Created in BioRender. Leventhal, M. (2025) https://BioRender.com/y28s838.
