Fig. 1: Selection of cancer of unknown primary cases for WGTS. | Nature Communications

Fig. 1: Selection of cancer of unknown primary cases for WGTS.

From: Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

Fig. 1: Selection of cancer of unknown primary cases for WGTS.

a Flow chart of CUP cases profiled in this study. Fresh or FFPE tumour samples were either diagnostic core needle biopsies or surgical resections accessed from pathology archives. Seventy-five samples from 74 CUP patients had WGTS performed, where 73 WGS and 69 WTS were successful. Seventy-one of these had matched panel sequencing: 24 using a custom cancer panel and 47 a commercial cancer panel. Created in BioRender. (License: Tothill, R. (2025) https://BioRender.com/h69j379). b Seventy-five tumours were sampled from a range of anatomical sites for molecular profiling in 74 CUP patients. Non-recurrent sites were combined as ‘other less common sites’. Created in BioRender. (License: Tothill, R. (2025) https://BioRender.com/r31l964). c Fraction of CUP tumours clinicopathology-resolved or clinicopathology-unresolved pre-genomic testing, after a centralised pathology review. Clinicopathology-unresolved CUPs were categorised based on a modified MSKCC OncoTree classification. Source data are provided as a Source Data file.

Back to article page