Fig. 5: Distribution of the case-control likelihood ratios for BRCA1 and BRCA2. | Nature Communications

Fig. 5: Distribution of the case-control likelihood ratios for BRCA1 and BRCA2.

From: Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

Fig. 5: Distribution of the case-control likelihood ratios for BRCA1 and BRCA2.

Histograms showing the distribution of case-control likelihood ratios (LRs) categorized by a sequence ontology variant consequence for BRCA1, b ClinVar classification for BRCA1, c sequence ontology variant consequence for BRCA2, d ClinVar classification for BRCA2. Histograms categorized by ClinVar classification are divided into two panels; the top panel represents variants curated in ClinVar as (likely) benign or (likely) pathogenic, while the bottom panel represents unclassified variants (variants not reported in ClinVar or listed in ClinVar as variants of uncertain significance or with conflicting classifications of pathogenicity). For visualization purposes the x axis represents log10(LR) values. Dashed lines represent LRs between 0.48 and 2.08 considered as of “No evidence”.

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