Fig. 8: The proposed model of hnRNPL phase separation promoting glycolysis in ovarian cancer.
From: hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer
In ovarian cancer cells, a non-coding RNA transcribed from the PIK3CB promoter recruits hnRNPL and promotes its condensation, which activates PIK3CB transcription and downstream AKT signaling pathway, thus promoting glycolysis and cancer progression.
