Fig. 1: Prime-and-trap malaria vaccination induces sex-specific protection against sporozoite challenge. | Nature Communications

Fig. 1: Prime-and-trap malaria vaccination induces sex-specific protection against sporozoite challenge.

From: Androgens inhibit protective CD8+ T cell responses against pre-erythrocytic malaria parasites in mice

Fig. 1: Prime-and-trap malaria vaccination induces sex-specific protection against sporozoite challenge.The alternative text for this image may have been generated using AI.

a Scheme of male (M) and female (F) BALB/cJ mice prime-and-trap (P&T) vaccination experiments. b Percentages of mice protected or not protected against challenge with 0.5 − 1.0 × 103 Py-WT sporozoites, as measured by blood parasitemia up to day 14 post-challenge. Numbers above bars indicate numbers of protected mice out of the total mice challenged, derived from 4 independent experiments. c Representative rainbow images of luminescence in livers 44 h post infection (hpi) with 1 × 104 Py-Luc sporozoites. Rainbow scales are expressed in radiance (p/s/cm2/sr). d Quantification of bioluminescent signal in log-transformed total flux (p/s) from mice at 44 hpi (2 independent replicates, n = 8–10/group). Groups in b were compared using a two-sided Fisher’s exact test, and groups in d were compared by a two-sided Wilcoxon test; only relevant comparisons are depicted. Error bars represent mean ± s.e.m; ns = p > 0.05, ***p < 0.001. Source data are provided as a Source Data file.

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