Fig. 7: AI-FM screens compound Y040-7904 as a potential mitophagy inducer. | Nature Communications

Fig. 7: AI-FM screens compound Y040-7904 as a potential mitophagy inducer.

From: An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates

Fig. 7

A Chemical structures and pseudo-colored intermediate distribution maps processed by DMAN after treatment with two established mitophagy inducers and nineteen test hit compounds. Blue: mitochondria, green: mitophagosomes, red: mitolysosomes. B The calculated proportion of two mitophagic intermediates in live HT22 cells after treatment with mitophagy inducers or the hit compounds under investigation. Source data are provided as a Source Data file. C Surface plasmon resonance (SPR) analysis offers concentration-dependent plots of Y040-7904 to SIRT1 protein. Source data are provided as a Source Data file.

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