Table 1 Averaged performance metrics across 100 replicates for remMap (r) and DrFARM (d) under different types of debiasing in Scenario II for simulation 1
From: DrFARM: identification of pleiotropic genetic variants in genome-wide association studies
| Â | Â | Â | Individual | Group | ||||
|---|---|---|---|---|---|---|---|---|
Method | Precision | Debiasing | TPR | FDR | MCC | TNR | FDR | MCC |
d | None | None | 99.7% | 27.2% | 85.0% | 61.6% | 65.9% | 45.8% |
d | Glasso | Outer | 99.3% | 5.6% | 96.8% | 99.0% | 5.4% | 96.8% |
d | Glasso | Inner | 95.2% | 0.7% | 97.2% | 99.0% | 5.3% | 96.8% |
d | Glasso | Double | 98.2% | 4.6% | 96.8% | 99.2% | 4.1% | 97.5% |
d | NL | Inner | 95.2% | 0.7% | 97.2% | 99.0% | 5.3% | 96.8% |
d | NL | Double | 98.0% | 4.6% | 96.7% | 99.3% | 4.0% | 97.6% |
d | QO | Inner | 95.4% | 0.6% | 97.4% | 99.2% | 4.4% | 97.3% |
d | QO | Double | 96.4% | 8.9% | 93.7% | 98.7% | 6.8% | 95.9% |
r | None | None | 94.2% | 15.6% | 89.1% | 86.7% | 41.6% | 71.0% |
r | Glasso | Outer | 90.8% | 5.3% | 92.7% | 98.9% | 5.9% | 96.4% |
