Fig. 9: Schematic diagram summarizing the HSV-1 rewiring of host chromatin. | Nature Communications

Fig. 9: Schematic diagram summarizing the HSV-1 rewiring of host chromatin.

From: Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking

Fig. 9: Schematic diagram summarizing the HSV-1 rewiring of host chromatin.The alternative text for this image may have been generated using AI.

During HSV-1 infection, RNAP II (light green), TOP1 (yellow) and cohesin (green rings) are hijacked to the VRCs. As a result, a host-to-virus transcriptional switch occurs, and the host chromatin becomes highly compacted and transcriptionally repressed. At the same time, HSV-1 is found to contact specific gene-rich regions of the host genome, forming new loops. These regions are transcriptionally active, and include genes involved in infection progression.

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