Fig. 1: Serum levels of FABP7 were higher in SPMS and showed correlation with EDSS score and brain volumetrics in MS patients. | Nature Communications

Fig. 1: Serum levels of FABP7 were higher in SPMS and showed correlation with EDSS score and brain volumetrics in MS patients.

From: FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch

Fig. 1: Serum levels of FABP7 were higher in SPMS and showed correlation with EDSS score and brain volumetrics in MS patients.

a, b Bars (mean ± SD) show serum levels of (a) FABP7 and (b) FABP4 in RRMS, and age-matched healthy controls (HC1) and in SPMS and age-matched healthy controls (HC2). One-way ANOVA was performed following correction with Šidák multiple comparison test, and P-values are shown above the comparisons (n = 32 of each group). c A negative correlation of FABP7 with BPF (n = 34). d, e A positive correlation of FABP7 with T1LV and T2LV (n = 34). f A positive correlation of serum FABP7 with EDSS score (n = 98). Two-sided simple linear regression analysis was performed for correlation and shown as a regression line (shaded area represents error of the regression line), data is adjusted for age and sex, and p-values were adjusted using Holm’s correction for (c–f). RRMS  Relapsing remitting MS, SPMS  Secondary progressive MS, BPF  Brain Parenchymal Fraction, T1LV  whole brain T1 hypointense white matter lesion volume, T2LV whole brain T2 hyperintense white matter lesion volume.

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