Fig. 4: FABP7 increased expression of inflammatory genes and gene enrichment associated with inflammatory pathways and glucose metabolism. | Nature Communications

Fig. 4: FABP7 increased expression of inflammatory genes and gene enrichment associated with inflammatory pathways and glucose metabolism.

From: FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch

Fig. 4: FABP7 increased expression of inflammatory genes and gene enrichment associated with inflammatory pathways and glucose metabolism.

a Volcano plot showing the distribution of overall transcriptomics in monocytes after FABP7 treatment. DESeq2 with a two-sided Wald test was performed for comparison. Data was adjusted for sex. b Heat map showing top 50 DEGs. c Dot plot of gene set enrichment analysis of GO biological pathways using ClusterProfiler. The pathways related to inflammation and chemotaxis were highlighted in the red box. d Pathway analysis of all significant DEGs using Human Cyc 2016 in Enrichr indicates gene enrichment for glucose metabolism. The tests conducted were two-sided, and p-values were adjusted using Benjamini-Hochberg to correct for multiple hypothesis testing for (c, d). DEGs  Differentially expressed genes.

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