Fig. 1: snRNA-seq indicates that adipose-resident c-kit+ cells are previously unidentified thermogenic APCs. | Nature Communications

Fig. 1: snRNA-seq indicates that adipose-resident c-kit+ cells are previously unidentified thermogenic APCs.

From: Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling

Fig. 1

A t-distributed stochastic neighbor embedding (tSNE) plot of cell nuclei isolated from iBAT of Kit-CreER; Rosa26-RFP mice after exposure to cold temperature for 4 weeks after tamoxifen (Tam) administration, showing 16 subpopulations. B Bubble plots showing expression levels and distributions of representative transcripts for the selected genes among different cell clusters. The dot size represents the percentage of cells that expressed the gene, and the color represents the scaled value of the average expression level of gene X in cluster Y. The average expression levels of genes are calculated by normalization of the transcriptome data (gene sequence reads by a factor of 10,000, with log-transformed). C Violin plots showing expression levels of representative transcripts for adipose progenitor marker genes, including Pdgfrα, Kit, Cd34, Ly6a, Dpp4, Trpv1, Ebf2, and Erbb4 in c-kit+ APCs and PDGFRα+ APCs. D Gene Ontology enrichment analysis of the transcripts significantly upregulated by cold stimulation in c-kit+ adipocyte progenitors.

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