Fig. 7: Association of chicken growth traits with complex traits in humans.
From: Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line
a Heatmap showing enrichments of five chicken growth traits (indicated at the bottom) associated with selected human traits and diseases (indicated at the left). “*” means 0.01 <p < 0.05, “**” means p < 0.01. b Homologs of functional genes of the chicken body weight (BW) phenotype influence the complex phenotype of humans (from the PheWAS database). c Examples of homologous genes of KCNRG related to chicken body weight phenotypes influencing important growth phenotypes in humans (the human PheWAS was performed using the GWAS atlas, https://atlas.ctglab.nl). d SNP annotation for SNPs converted to human homologs based on the SNPs obtained from SMR affecting chicken growth traits (A total of 173 unique SNPs were obtained, of which 32 were successfully converted to that of humans using the UCSC liftover tool.) e We analyzed genes affecting five phenotypes in chickens and human homologous genes’ intron, exon, and intergenic region lengths. Orange indicates the exon, blue indicates the intron, and gray denotes the intergenic region.
