Fig. 1: Schematic illustration of the preparation of OSA-GEL@GC hydrogels, and their effect on diabetic wound healing. | Nature Communications

Fig. 1: Schematic illustration of the preparation of OSA-GEL@GC hydrogels, and their effect on diabetic wound healing.

From: Microenvironment-feedback regulated hydrogels as living wound healing materials

Fig. 1: Schematic illustration of the preparation of OSA-GEL@GC hydrogels, and their effect on diabetic wound healing.

A The hydrogel precursors and the formation of OSA-GEL@GC hydrogels. B The working mechanism of microenvironment-feedback (pH and glucose) regulatory hydrogel: (i) Formation of OSA-GEL@GC with alkaline pH as the fuel. (ii) Encapsulated GOx consumes local blood glucose, produces gluconic acid as an anti-fuel and gradually dissociates the formed hydrogel. (iii) The released GOx further consumes glucose in the wound-bed, resulting in a decreased blood glucose level (BGL) in wound microenvironment. (iv) Decreased BGL halts a series processes of gel acidification/degradation and GOx release, countering a continuous descend of BGL. C Schematic illustration of OSA-GEL@GC dressing for accelerating diabetic wound healing.

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