Fig. 6: Maximum likelihood phylogenetic tree of the pre-microcin amino acid sequences of 31 active novel microcins and 10 verified microcins from the Enterobacteriaceae.
From: Antibacterial microcins are ubiquitous and functionally diverse across bacterial communities
Two Gram-positive double-glycine signal-containing bacteriocins (Pediocin PA-1 and Piscicolin-126) are included as the outgroup. Branch support values < 50% are collapsed. The eight major clades are each indicated in a different color. The taxonomic clade of origin29 of the strain from which the microcin originated is indicated by a symbol. Class IIb microcins are indicated by ‘IIb’; the remainder are class IIa. Alternate names for 4 class IIb microcins concurrently identified by another group32,33 are noted in blue text. Outer circles indicate proteins involved in microcin uptake and mechanism of action, by clade: red = outer membrane (OM) receptor, yellow = uptake mechanism and/or proteins that act in the periplasm, and blue = inner membrane (IM) receptor/target/other requisite interior proteins. Proteins were explicitly identified (here and/or in previous literature, Table 1) for underlined microcins; they are inferred based on sequence similarity for non-underlined microcins.
