Fig. 1: β-Lactam antibiotic resistance mechanism and overall structures of AmpG. | Nature Communications

Fig. 1: β-Lactam antibiotic resistance mechanism and overall structures of AmpG.

From: Structural and functional insights of AmpG in muropeptide transport and multiple β-lactam antibiotics resistance

Fig. 1: β-Lactam antibiotic resistance mechanism and overall structures of AmpG.The alternative text for this image may have been generated using AI.

a Chemical structures of GlcNAc-1,6-anhydroMurNAc and its pentapeptide derivative. The red circle marks the peptide conjugation site. b Schematic of the AmpC induction pathway of AmpG. c Overall structure of AmpG in the apo outward state (green)(PDB:8ZBB), the outward state complexed with GlcNAc-1,6-anhMurNAc (cyan)(PDB:9J9Z), the inward-occluded state complexed with GlcNAc-1,6-anhMurNAc (orange)(PDB:8ZKE), and the apo inward state (magenta)(PDB:8ZGZ). AmpG: Anhydromuropeptide permease G, AmpR: AmpC regulator, ampC: β-lactamase gene, LT: Lytic transglycosylase, Ami: N-acetylmuramoyl-L-alanine amidase, PBP: Penicillin-binding protein, NagZ: N-acetyl-β-D-glucosaminidase Z.

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