Fig. 1: Intracellular supramolecular assemblies directed protein degradation. | Nature Communications

Fig. 1: Intracellular supramolecular assemblies directed protein degradation.

From: In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation

Fig. 1: Intracellular supramolecular assemblies directed protein degradation.

In the cell-selective in situ supramolecular assembly process, tetrazine-bearing nanofibers were constructed to entrap specific proteins. The subsequent ligation with E3 recruiters induced the proximity between the trapped proteins and the E3 ligase, which facilitated the degradation of the trapped proteins.

Back to article page