Fig. 7: The ROS-instructed supramolecular self-assembly. | Nature Communications

Fig. 7: The ROS-instructed supramolecular self-assembly.

From: In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation

Fig. 7: The ROS-instructed supramolecular self-assembly.

a Molecular structure of the precursor BQA-K(Tz)GGGFF after oxidation and bioorthogonal reaction with TP2T to yield SA-PROTAC-2. b TEM image of the nanofibers in a 2.5 mM BQH-K(Tz)GGGFF hydrogel (inset). Scale bar: 200 nm. c HPLC traces were used to monitor the bioorthogonal reaction between BQA-K(Tz)GGGFF and TP2T. The TEM (b) was repeated three times with similar results. Source data are provided as a Source Data file.

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