Fig. 8: Modulation of tongue inflammation by nanoplatforms in a mouse model. | Nature Communications

Fig. 8: Modulation of tongue inflammation by nanoplatforms in a mouse model.

From: Nanostructured organic sheets sequestering small extracellular vesicles and reactive species to protect against radiation-induced mucositis

Fig. 8: Modulation of tongue inflammation by nanoplatforms in a mouse model.

a The relative sEVs, GSH, SOD, and MDA level in OLF from experimental mice. b t-SNE analysis of CD45+ cells in tongues of experimental mice after treatments, and the M1/M2 ratio of macrophages calculated by flow cytometry. c Representative H&E staining images of the tongues from experimental mice. Scale bars: 250 µm. d Quantification of epidermis thickness in H&E staining images. e, Representative CK5 immunostaining images of the tongues from experimental mice. Scale bars: 100 µm. f Quantification of relative CK5 positive area in immunostaining images. Data represent the mean ± S.D. (n = 6 mice). Statistical significances were assessed by one-way ANOVA (a, b, d, and f), and multiple comparisons post hoc tests were performed via the Prism recommendation (Tukey or Dunnett) method. Abbreviations: OLF: oral lavage fluid; GSH: glutathione; SOD: superoxide dismutase; MDA: malondialdehyde; CK-5: cytokeratin 5. Source data are provided as a Source Data file.

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