Fig. 6: Benchmarking and further methodological diversification of the BYO thiol-thiol cross-click reaction. | Nature Communications

Fig. 6: Benchmarking and further methodological diversification of the BYO thiol-thiol cross-click reaction.

From: Thiol-thiol cross-clicking using bromo-ynone reagents

Fig. 6

Cysteine competition experiments of bromo-ynone and a maleimide bioconjugation reagent (a), cysteine competition experiments of thio-ynone and a maleimide bioconjugation reagent (b), cysteine competition experiments of bromo-ynone and a dibromomaleimide bioconjugation reagent (c), diastereoselective amine addition (d), thio-ynone competition with lysine and benzylic and aromatic amines (e), heterocyclization reactions with 1,2-dinucleophiles (f, g). For direct competition experiments between thiols and the nucleophiles listed here, see supplementary section 2.4.

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