Fig. 4: Cranial 18F-FDS PET imaging in patients.
a Representative transverse (upper) and coronal (lower) CT (left) and 18F-FDS PET/CT (right) images from a patient with confirmed invasive cerebral mold infection (patient 1). b Representative control patients without cerebral disease (control 2). c Representative transverse MRI and 18F-FDS PET/MRI images from patient 1. The research PET was co-registered with the MRI performed for clinical reasons. d TNT measurements derived from patients with invasive cerebral mold infections (n = 2), and the control patients without cerebral pathology (n = 5) with n = 2 VOIs per patient (patient 4 with mold infection has 1 VOI only). 18F-FDS PET signal was significantly higher at the sites of invasive cerebral mold infections compared to controls (P = 0.007). Data are shown on a log scale as median ± IQR. Statistical analyses were performed using a two-tailed Mann-Whitney U test.
