Fig. 8: Schematic diagram of RIPK4 regulating bone and bone marrow homeostasis via MFN2. | Nature Communications

Fig. 8: Schematic diagram of RIPK4 regulating bone and bone marrow homeostasis via MFN2.

From: RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer

Fig. 8: Schematic diagram of RIPK4 regulating bone and bone marrow homeostasis via MFN2.

In normal conditions, RIPK4 in osteolineage cells regulates osteogenesis and hematopoiesis by phosphorylating mitochondrial fusion protein MFN2 to regulate mitochondrial dynamics. When RIPK4 is ablated, mitochondrial dynamics was disturbed due to the interruption of RIPK4-MFN2 axis, leading to the impaired osteogenesis and promoted myeloid-biased hematopoiesis, thus resulting in severe osteoporosis and myeloid-biased hematopoiesis. This figure was created by P.D. and cartoonized by Mr. Zihao Li using Procreate software.

Back to article page