Fig. 1: Enantioselective reactions of allenylic derivatives with C-/N-nucleophiles and secondary phosphine oxides.
From: P-stereogenic centre via Pd/Cu-bimetallic catalytic selective phosphinylation of allenylic acetates
a Pd-catalyzed dynamic kinetic transformation of racemic allenylic derivatives for chiral allene synthesis (previous work); b The challenges in Pd-catalyzed asymmetric reaction of racemic allenylic derivatives with racemic secondary phosphine oxides; c This work: Pd/Cu-cocatalyzed regio-, E- and enantioselective phosphinylation of allenylic esters with racemic alkyl aryl phosphine oxides.
