Fig. 2: Identification of tumor-specific genes and pathways in WT.

a Venn diagram depicting the overlap of genes upregulated in WT (Wilms tumor) for RNAs, proteins, and phosphorylated proteins. b Venn diagram depicting the overlap of genes downregulated in WT for RNAs, proteins, and phosphorylated proteins. c Boxplot showing the Z-score normalized RNA (upper panel) and protein (lower panel) abundance of the indicated genes in WT (RNA: n = 62, protein: n = 88) and NAT (normal adjacent to tumor) (RNA: n = 37, protein: n = 71). A two-sided Wilcoxon rank sum test was performed to determine the difference. Boxplots show median value, box indicates 75 and 25th quartile and whiskers extend to the farthest value (largest and smallest). d The pathways enriched by the upregulated (left) and downregulated (right) RNAs/proteins/phospho-proteins in WT compared to NAT. Bold texts represent categories of enriched pathways. Each circle represents one pathway, and the pathways are connected if they shared 20% genes. The colors within the nodes represent the omics data. e Representative genes involved in the pathways enriched by the differentially expressed RNAs/proteins between WT and NAT. f The kinases with differential activities between WT and NAT inferred by differently phosphorylated sites. Source data are provided as a Source Data file.