Fig. 2: Spatiotemporal profiling of cellular dynamics during acute kidney injury and repair in mice.
From: Multimodal spatial transcriptomic characterization of mouse kidney injury and repair
A Spatiotemporal distribution of cell types within selected kidney regions, spanning from control (Sham) through AKI progression and repair time course. For each time point, cellular composition from cortex to medulla are visualized. Pod, podocytes; Glom-EC, glomerulus endothelial; PTS1, S1 segment of proximal tubule; PTS2, S2 segment of proximal tubule; PTS3, S3 segment of proximal tubule; Inj-PT, injured proximal tubule; FR-PT, failed repair proximal tubule; DTL, descending limb of loop of Henle; TAL, thick ascending limb of loop of Henle; DCT, distal convoluted tubule; CNT, connecting tubule; PC, principal cells; ICA, type A intercalated cells; ICB, type B intercalated cells; Uro, urothelium; PEC, parietal epithelial cells; EC, endothelial cells; Fib, fibroblasts; Per-SMC, pericytes and smooth muscle cells. B Heatmap displaying representative differentially expressed genes across major cell populations. C UMAP projection of major cell types identified using Xenium platform. D Representative PAS images of major cell types with corresponding marker gene expression patterns in spatial context. Scale bar: 50 μm.
