Fig. 2: Characterizing F1 – the genetics of birth size.
From: Modeling the genomic architecture of adiposity and anthropometrics across the lifespan
The 3 indicator variables relating to birth size and their standardized loadings on F1, the 1st latent genetic factor, are shown in (a). This genetic factor did not have any genetic enrichment across physiological systems, cell types, or tissue types (FDR < 0.05) in the DEPICT enrichment analysis (b). The polygenic score (PGS) weights for F1 were applied in an external sample (CCPM Biobank, N = 25,240) and implemented in a phenome wide association study (pheWAS); The significant logistic regression pheWAS associations between F1 PGS and phenotypes are shown in (c), with phenotype labels for the points to the right of the vertical dashed red line denoting the FDR < 0.10 Bonferroni-corrected significance threshold, and triangle direction (up/down) indicating F1 PGS direction of effect (+/−). Source data are provided as a Source Data file.
