Fig. 6: Network of genetic correlations with the 4 factors.
From: Modeling the genomic architecture of adiposity and anthropometrics across the lifespan
A network with edges depicting the strength of genetic correlations between the 4 Genomic SEM factors and an array of genetically related traits. Small pairwise correlations ≤ 0.15 were pruned from the network highlighting this subset of 33 genetically correlated traits from a broader set of 75 considered traits (see Supplementary Table 3). The 4 factors had weak between-factor genetic correlations (besides F1 and F3) and their unique genetic signals are characterized by each factor’s grouping with a distinct, but not entirely exclusive, set of phenotypes. Trait names and abbreviations in alphabetical order: Alcohol Consumption Frequency (ACF); Attention-Deficit Hyperactivity Disorder (ADHD); Age of Smoking Initiation (AgeSI); Anorexia Nervosa (AN); Anxiety Disorders (ANX); Adult-Onset Asthma (AsAO); Atrial Fibrillation (AtrFib); Coronary Artery Disease (CAD); Cigarettes Per Day (CPD); Cannabis Use Disorder (CUD); Personality - Extraversion (Extrv); F1 - Birth Size (F1); F2 - Abdominal Size (F2); F3 - Body Size, Adipose Distribution (F3); F4 - Adiposity (F4); Fasting Glucose (FastGluc); Cardiorespiratory Fitness - Heart Rate (FitHR); Cardiorespiratory Fitness - VO2 Max (FitVO2); Frailty Index (Frail); High-Density Lipoprotein Cholesterol (HDL); Metabolic Syndrome (MetSyn); Neuroticism (Neur); Neuroticism - Depressed Affect (NeurD); Neuroticism - Worry (NeurW); Obsessive Compulsive Disorder (OCD); Pain - General (PainG); Pain - Musculoskeletal (PainM); Problematic Alcohol Use (PAU); Physical Activity (PhysA); General Risk-Tolerance (Risk); Systolic Blood Pressure (SBP); Smoking Cessation (SC); Smoking Initiation (SI); Sleep Efficiency (SleepE); Type 2 Diabetes (T2D); Triglycerides (Triglyc); Serum Urate - Gout (Urate). Source data are provided as a Source Data file.
