Fig. 5: Il4i1-Il23aOE mice develop psoriatic arthritis-like symptoms.
From: CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse
a Representative macroscopic views of the paws of 16-week-old LSL-Il23a mice (n = 5) and Il4i1-Il23aOE mice (n = 5). b Representative H&E images of the hind paws from 16-week-old LSL-Il23a mice (n = 3) and Il4i1-Il23aOE mice (n = 6). Scale bar, 100 μm. c Heatmap of selected genes from bulk RNA-seq data of the metacarpal and phalangeal bones from 16-week-old LSL-Il23a mice (n = 3) and Il4i1-Il23aOE mice (n = 4). The GO categories are indicated. d Representative microCT images of the hind paws from 25 to 29-week-old LSL-Il23a mice (n = 8) and Il4i1-Il23aOE mice (n = 11). Scale bar, 1 mm. e Representative microCT images of the metatarsal bones proximal to the metatarsophalangeal joints from 25 to 29-week-old LSL-Il23a mice (n = 8) and Il4i1-Il23aOE mice (n = 11). II, III and IV represent three different toes of the mice. Scale bar, 1 mm. f Quantification of bone structural parameters of 25 to 29-week-old LSL-Il23a mice (n = 8 with 2 hind paws per mouse) and Il4i1-Il23aOE mice (n = 11 with 2 hind paws per mouse) shown in (e). Data represent the 25th to 75th percentiles (whiskers showing min to max and center showing the mean value). P-values were determined by two-tailed unpaired t-test. Ct. Th cortical bone thickness, Ct. Ar cortical bone area, Tt. Ar total area of the cross section, BV/TV bone volume to total volume ratio, ns not significant. For P < 0.0001, the exact P-values are 9.6e−11 (Ct. Th), 3.9e−9 (Ct. Ar), and 5.9e−10 (BV/TV). Data (a, b, d–f) are representative of three independent experiments. Source data are provided as a Source Data file.
