Fig. 6: CCR7⁺ DC define a type 17 spatial module in psoriatic epidermis.

a Spatial feature-plots of KLRB1 and LAMP3 in psoriatic skin section from a patient. b Representative immunofluorescent labeling of CD161, LAMP3 and KRT17 in psoriatic skin (n = 3). Scale bar, 25 μm. Data are representative of two independent experiments. c Chemokine receptor-ligand pairs across cell subpopulations within psoriatic skin. All interactions shown are statistically significant (P < 0.05), and arrows denote directionality from ligand to receptor. d A working model of chemotaxis of CCR7⁺ DC and CD161⁺ T cells in psoriatic skin. e CD4^-CD44⁺CD62L⁺ Tcm cells sorted from spleens of Il4i1-Il23a^OE mice were co-cultured for 36 h respectively with cDC1, cDC2, DC3, LC, macrophages and CCR7⁺ DC isolated from the skin and lymph nodes of Il4i1-Il23a^OE mice without adding exogenous antigens and flow cytometry was used to analyze the percentages of IL-17a⁺ cells in T cells (n = 4). Data represent the mean ± SEM. P-values were determined by one-way ANOVA. Data are representative of three independent experiments. Source data are provided as a Source Data file.