Fig. 5: ISR genes are dysregulated in spinal cord tissue and CSF from individuals with ALS. | Nature Communications

Fig. 5: ISR genes are dysregulated in spinal cord tissue and CSF from individuals with ALS.

From: Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

Fig. 5

a Density plot of ISR gene set (orange line) in cervical spinal cord tissue from Target ALS dataset. b Normalized ISR gene expression plots comparing Control and ALS from cervical spinal cord. Samples are from the Target ALS dataset and include cervical spinal cord tissue with n = 116 for ALS samples and n = 16 for control samples. c Non-age adjusted CSF GDF-15 concentration (pg/mL) in healthy participants (n = 47) and ALS participants (n = 27) at baseline. d Age adjusted CSF GDF-15 concentration (pg/mL) in MAD healthy participants (n = 47) and ALS participants (n = 27) at baseline. Data shown as Min-to-Max Box plots overlayed with individual values (b−d). Statistical significance was determined with Two-tailed Mann-Whitney test. Source data are provided in Source Data file.

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