Fig. 8: Schematic model illustrating STN1 drives PDAC metastasis through promoting transcription of EMT-TF ZEB1. | Nature Communications

Fig. 8: Schematic model illustrating STN1 drives PDAC metastasis through promoting transcription of EMT-TF ZEB1.

From: STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer

Fig. 8: Schematic model illustrating STN1 drives PDAC metastasis through promoting transcription of EMT-TF ZEB1.

Created in BioRender. Dong, D. (https://BioRender.com/q05s064.). HOXB7 upregulates STN1 in PDAC tumors. The elevated STN1 then binds to structurally displaced single-stranded DNA adjacent to R-loops in the EMT-TF ZEB1 promoter region. This facilitates STAT3 recruitment, which promotes transcription of ZEB1, thereby activating epithelial-mesenchymal transition and metastatic progression.

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