Fig. 1: SNP heritability of brain IDPs and behavioral phenotypes in individuals of European ancestry.
From: Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children
A Estimated SNP heritability of brain imaging-derived phenotypes (IDPs) (Vg/Vp), where O denotes significant estimates and X denotes non-significant estimates. B Estimated SNP heritability of behavioral phenotypes, with colored bars representing significant heritability estimates and unfilled bars representing non-significant estimates. C Bars show mean ± SE SNP heritability for all significant brain imaging (n = 1237 IDPs) and behavioural phenotypes (n = 34 traits; FDR < 0.05). Dots mark the individual point estimates for each phenotype. SNP-based heritability reflects the proportion of variance in a trait explained by genetic variations, specifically single-nucleotide polymorphisms (SNPs). In the ABCD youth sample, heritability was estimated using a linear mixed model framework, fitting all common SNPs as random effects to quantify their contribution to trait variance. IDP imaging-derived phenotype, SE standard error, SNP single-nucleotide polymorphism, FDR false-discovery rate.
