Fig. 2: Brain morphometric regions show significant associations with PGS.
From: Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children
Heat-maps show significant loadings of cortical and subcortical morphometric measures and PGS across canonical components from the two-block CCA of PGS versus structural MRI (sMRI). A Surface area, (B) volume, (C) thickness, (D) mean curvature, (E) subcortical volumes, (F) white-matter measures, (G) PGS. Colour scale (right) ranges from – 1 (blue) to + 1 (orange-red). Regions significant in both two-block and three-block analyses are outlined and marked with an asterisk (*). Significance was set at FDR-corrected P < 0.05. sMRI structural magnetic-resonance imaging, PGS polygenic score.
