Fig. 5: ProtacID was conducted on three BET domain-directed PROTACs.
From: Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Two VHL-recruiting BET PROTACs (MZ1 and ARV-771) and one CRBN-recruiting BET PROTAC (dBET6) were subjected to ProtacID, as indicated. For comparison, standard BioID was also conducted on FmT-BRD2, FmT-BRD3, and FmT-BRD4 in 293 cells. Blue font indicates PROTAC neo-substrates.
