Fig. 1: Cryo-EM structures of LGR4 alone and in complex with RSPO2(FU). | Nature Communications

Fig. 1: Cryo-EM structures of LGR4 alone and in complex with RSPO2(FU).

From: Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy

Fig. 1: Cryo-EM structures of LGR4 alone and in complex with RSPO2(FU).The alternative text for this image may have been generated using AI.

a Structure of the LGR4-MB52 complex. The cryo-EM map contoured at 0.157 (13.7σ) (left) and atomic model (right) are shown. b Structure of the MB52-LGR4-RSPO2(FU) complex. The cryo-EM map contoured at 0.153 (7.87σ) (left) and atomic model (right) are shown. c Interface between LGR4 and RSPO2(FU). d The cryo-EM densities for the interaction interfaces between LGR4 and RSPO2(FU) contoured at 0.153 (7.87σ). Interacting residues are drawn as sticks. LGR4 cyan, RSPO2(FU) purple, MB52 gray. The same color scheme is used throughout the manuscript unless stated otherwise.

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