Fig. 5: Effect of T2D PRS on diabetes-related traits meta-analyzed across PAGE and the additional biobanks and cohorts.
From: Polygenic risk score for type 2 diabetes shows context-dependent effects across populations
The X-axis represents the beta estimates and 95% confidence intervals (CIs) of PRS for continuous traits and odds ratios (OR) and 95% CIs of PRS for binary traits. P-values shown on each plot are exact values derived from two-sided linear regression models for continuous traits and two-sided logistic regression models for binary traits. Solid circles indicate significant associations that passed the Bonferroni-adjusted P-value threshold of P < 2.50 × 10−3, while open circles indicate associations that were not significant. Panels show associations for the T2D PRS and A glycemic traits in T2D controls and B cardiometabolic traits in T2D cases (left), controls (middle), and individuals with prediabetes (right). The units of continuous traits are listed in Supplementary Data 13. Sample sizes are provided in Supplementary Data 14. Results for vascular disease, kidney function related traits, and inflammatory biomarkers are shown in Supplementary Fig. 4.
