Fig. 3: No widespread detection of pairwise epistasic interactions in the HMDP. | Nature Communications

Fig. 3: No widespread detection of pairwise epistasic interactions in the HMDP.

From: Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits

Fig. 3

The percentage of all HMDP pairwise interacting loci with consistent direction of effects in the two sexes was plotted according to the male-derived p values. Interaction p values > 0.95 were excluded due to many low-frequency alleles. Directionality was determined using the sign of the Beta value for each interaction. The phenotypes measured included A metabolic traits, B blood traits, and C simulated phenotypes (n = 10 simulations per group) using an increasing number of “causal” SNPs. Error bars were calculated using ggplot2 as mean values ±standard deviation.

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