Fig. 5: Sample size is critical for detecting concordant effects between males and females. | Nature Communications

Fig. 5: Sample size is critical for detecting concordant effects between males and females.

From: Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits

Fig. 5

The percentage of all UK Biobank main effect loci for BMI with consistent direction of effects in the two sexes was plotted according to the male-derived p values. Samples were randomly downsampled to simulate smaller sample sizes. Main effect p values > 0.95 were excluded due to many low-frequency alleles. Directionality was determined using the sign of the effect size of each main effect loci.

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