Fig. 7: Model of TLK2 suppression in disrupting CTCF-cohesin hub formation to target cancer stemness plasticity. | Nature Communications

Fig. 7: Model of TLK2 suppression in disrupting CTCF-cohesin hub formation to target cancer stemness plasticity.

From: Chromatin looping-based CRISPR screen identifies TLK2 as chromatin loop formation regulator in cancer stemness plasticity

Fig. 7: Model of TLK2 suppression in disrupting CTCF-cohesin hub formation to target cancer stemness plasticity.

Upper left, Schematic summarizing the identification of TLK2 as a regulator of CTCF-cohesin hub formation through CTCF-cohesin hub reporter and CRISPR screening. Upper right, Schematic illustrating the role of the TLK2-DYNLL1 axis in regulating CTCF-cohesin hub formation in proximity to the KLF4 stemness gene. Lower, Schematic depicting the suppression of CTCF-cohesin hub formation by targeting TLK2, inhibiting cancer stemness plasticity.

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