Fig. 1: EVG7 exhibits potent in vitro activity against human C. difficile isolates. | Nature Communications

Fig. 1: EVG7 exhibits potent in vitro activity against human C. difficile isolates.

From: Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family

Fig. 1

Minimal Inhibitory Concentration (MIC) of vancomycin (VAN) and EVG7 against C. difficile clinical isolates, determined by agar dilution method in Brucella Blood Agar (BBA) supplemented with sheep blood, hemin, and vitamin K. The isolates tested belong to a well-established reference collection88,89 supplemented with clinical isolates collected by the National Expertise Center for C. difficile infections (hosted at the Leiden University Medical Center (LUMC), the Netherlands)106. Each dot represents the MIC value for an independent single isolate, the lines represent the geometric mean MIC value in this clade for each compound (independent biological replicates). Graphs were generated in GraphPad Prism 10 and further compiled in Adobe Illustrator 2024. Source data are provided in Supplementary Table 1 and as a Source Data file.

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