Fig. 4: Associations of serum proteins with clinical milestones. | Nature Communications

Fig. 4: Associations of serum proteins with clinical milestones.

From: Large-scale serum protein biomarkers discovery associated with function and clinical milestones in Duchenne muscular dystrophy

Fig. 4: Associations of serum proteins with clinical milestones.The alternative text for this image may have been generated using AI.

LoA: LUMC n = 74, UF n = 78; OHR LUMC n = 74, UF n = 76; HTM LUMC n = 74, UF n = 77. a Survival curves showing the probability (y-axis) of never achieving LoA, loss of OHR, and loss of HTM (solid/dashed/dotted lines) by age in each cohort. b UpSetR plot of probes significantly associated with each clinical milestone by the Cox model. Bar plots at the bottom-left show the number of probes associated with each individual milestones, color coded by site. c Forest plot showing lnHR (x-axes) of protein probes (y-axes) significantly associated (FDR < 0.05) with at least one clinical milestone. Points represent the estimated lnHR, error bars represent the 95% confidence intervals. Each panel shows the proteins associated with an individual milestone. d Survival curves for the 3 clinical milestones (columns) stratified by RGMA expression quartiles at first visit (colors), by years since first visit (x-axes). The first row represents curves for LUMC, the second row represents curves for UF. (HTM hand-to-mouth, LoA loss of ambulation, OHR overhead reach, UF University of Florida, LUMC Leiden University Medical Center). Source data are provided as a Source Data file.

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