Fig. 2: Direction-selective responses in the dLGN show topographic variation that aligns with translatory optic flow. | Nature Communications

Fig. 2: Direction-selective responses in the dLGN show topographic variation that aligns with translatory optic flow.

From: Differential topographic organization and retinal inheritance of direction and orientation selectivity in the visual thalamus

Fig. 2: Direction-selective responses in the dLGN show topographic variation that aligns with translatory optic flow.

a Receptive field of example unit. Positive and negative values represent On and Off responses, respectively. b Locations of receptive field centers of dLGN units (n = 1108), aligned to contralateral/ipsilateral visual fields. Red dot is example unit from a. c Receptive fields of one example recording colored by depth from pia. d Pairwise receptive field distance vs. distance along probe track for dLGN units. 3D model of histologically derived locations (e) and receptive field locations (f) of dLGN units, color-coded as in (c). These panels include units from Figs. 2b and 4c. g Left: Receptive field locations of non-DS (gray) and DS (red) units of dLGN-shell. Some receptive fields were estimated according to neighboring units (Methods). Binocular border is shown as mean ± SD (shaded area). Right: Proportion of DS units out of all units from the dLGN-shell. Significance was tested against shuffled data (two-sided; see Methods). p-values are indicated according to higher (§) or lower (*) percentage than chance. Gray asterisks indicate bins with <5 units. No corrections for multiple comparisons were made. h Like g for dLGN-core. i Left: Arrows of PDs of DS units from the dLGN-shell plotted on their receptive field, for DS units with PD in postero-inferior quadrant. Right: PD vs. elevation, colored by PD. R and p-value according to Pearson correlation. Shaded area indicates 95% confidence interval of fit. j Translatory optic flow during forward motion. k Calculated optic flow (black) at each visual field location corresponding to DS units’ receptive fields. PDs from i are overlaid. Close-ups show example regions. l Same as k but after rotating optic axis downward by 34°. m Distribution of angular difference between PDs and expected translatory optic flow at each unit’s receptive field location for the vertical optic axis positions shown in k and l. n Optic axis measured during experiment (blue), and its position after changing the optic axis elevation in a calculation (yellow). PD preferred direction, AP antero-posterior, ML medio-lateral, DV dorso-ventral. */§: p < 0.05, **/§§: p < 0.01, ***/§§§: p < 0.001, ****/§§§§: p < 0.0001.

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